Osaka Gas provides ketone bodies
that the company developed with
its proprietary fermentation technology.
A ketone body is a collective term for D-β-hydroxybutyrate (D-BHB), acetoacetate, and acetone, which are produced inside the human body. It is known that we have D-BHB the most inside our body compared to the other ketones. Under the conditions such as carbohydrates restriction or fasting, triglycerides are broken down and converted to D-BHB in the liver. Then D-BHB transfers into the blood and move around the whole parts of body, where it produces energy.
Once D-BHB is taken up into cells, it tranfers to mitochondria directly and turns out to be energy. It has been reported that D-BHB is preferentially consumed to produce energy over carbohydrate.
It has been reporeted that oral intake of D-BHB increased the blood ketone levels by about 2.5 times as much as that of MCT (medium-chain fatty acids).
registered for Foods with Function Claims
Ref.) J Nutr Sci Vitaminol,2023 69, 121)
A daily intake of D-BHB (2.9g) for 12 weeks resulted in a significant reduction in visceral fat
| Intake | Daily intake of one drink with 2.9 g of D-BHB / no restriction on diet and exercising |
|---|---|
| Examinee | BMI: 23-30 kg/m², healthy adult males and females aged 20 years or older/placebo: 22 persons, with D-BHB: 21persons |
| Evaluation items | Visceral fat area (abdominal CT scan) |
| Test period | 12 weeks |
Receipt of notification to the Consumer Agency of D-BHB as a novel functional ingredient
| Notification number | I1102 |
|---|---|
| Recommended daily intake | 2.9g per day as D-β-hydroxybutyrate |
| Claims | It has been reported that D-β-hydroxybutyrate has a function that enebles people with higher BMI to reduce visceral fat. |
※This notification is based on a systematic review (SR) in compliance with PRISMA statement 2020.
Investigation on the subjective symptoms after a daily intake of D-BHB (2.9 g/day) for 4 weeks
| Intake | Daily intake of one drink with 2.9 g of D-BHB |
|---|---|
| Examinee | 22 healthy adult males and females with the age of 20 years and older who are unsatisfied with their sleep quality |
| Evaluation items | OSA sleep inventory MA version (OSA-MA). |
| Test period | 4 weeks (2 times examination conducted before and four weeks after intake) |
Ref.) Med Sci Sports Exerc.2023 ;55(7):1184-1194
| Test Design | 10-week-old Sprague-Dawley rats were randomly divided into 3 groups that are required to do 3 types of exercise Placebo and BHB treatment groups were set for the 3 groups (total of 6 groups, n=6 per group). |
|---|---|
| Adiministration | Hypodermic injection of BHB (1000mg/kgBW) was given 10 min before each exercise |
1Human Overdose Test (for 12 weeks)
No adverse events after repeated administration (16 g/day)
2Rat Single-Dose Test
No deaths after oral administration of 2,000 mg/kg
3Rat Repeated Dose Test (for 28 days)
No toxic reaction after oral administration (2,000 mg/kg/day)
4Ames Test
No genetic mutagenicity for the five indicator strains.
1: Biosci Biotechnol Biochem. 2024 Jun 27:zbae088, 2~4: In-house test data
| Product name | OKETOA® D-BHB Acid |
|---|---|
| Generic name | (D)-β-hydroxybutyrate. |
| Labeled name | Fermented ketone-body D-BHB |
| Main raw materials | Sucrose |
| Raw material category | Food |
| Appearance | Clear to light yellow liquid |
|---|---|
| D-BHB content | 38-42％ |
| Arsenic | ≦0.5ppm |
| Cadmium | ≦0.5ppm |
| Lead | ≦0.5ppm |
| Mercury | ≦0.1ppm |
| Viable bacteria | ≦3,000cfu/g |
| Coliform bacteria | Negative |
| Storage Precautions | Store at less than 10℃ |
| Allergen (28 items) labeling | Not applicable |
| Genetically modefied labeling | Non-genetically modified |
| Product name | OKETOA® D-BHB Salt ions |
|---|---|
| Generic name | (D)-β-hydroxybutyrate neutralizing salt. |
| Labeled name | Fermented ketone-body D-BHB Na, Mg, Ca |
| Main raw materials | Sucrose |
| Raw material category | Food |
| Salt ions | Na | Mg | Ca |
|---|---|---|---|
| Appearance | WHITE TO LIGHT YELLOW POWDER | ||
| D-BHB content(as dry powder) | ≧72％ | ≧80％ | ≧73％ |
| Water content | ≦5％ | ≦7％ | ≦7％ |
| Arsenic | ≦0.5ppm | ||
| Cadmium | ≦0.5ppm | ||
| Lead | ≦0.5ppm | ||
| Mercury | ≦0.1ppm | ||
| Viable bacteria | ≦3,000cfu/g | ||
| Coliform bacteria | Negative | ||
| Storage Precautions | Store at 25℃ or below, away from direct sunlight and heat and moisture. After opening, avoid moisture, store in a sealable container, and use as soon as possible. |
||
| Allergen (28 items) labeling | Not applicable | ||
| Genetically modefied labeling | Non-genetically modified | ||
Related links
The development story of OKETOA® D-BHB is disclosed on the website. Please take a look.
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